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Polyclonal Antibody Production

For over 30 years, Noble Life Sciences has supplied the research community with GLP and non-GLP custom polyclonal antibody services using a variety of animal species including mouse, rat, rabbit, guinea pig, ferret, sheep and goat. Client-specific protocols have been used as well as Noble-developed standard immunization protocols. Peptide conjugation, antibody titer analysis via ELISA, and antibody purification from serum are available. Peptide sequence analysis and synthesis are also available. Further extension of custom polyclonal services includes performing immunogenicity and efficacy studies in rats, mice and rabbits for large and small pharmaceutical companies. Click here for an overview of our custom polyclonal  antibodies services.

Noble Life Sciences offers two protocols for maximizing antibody production in terms of levels of antibody, avidity and volume of serum. Each protocol is available in mouse, rat, rabbit, guinea pig, ferret, sheep and goat. Other species are available upon request. 

Standard ProtocolFast Protocol

Antigen Preparation

Noble can accept antigen for immunization in any form including, but not limited to, in solution, as a precipitate, as a cell suspension, as a band in acrylamide gel, or as a blot on nitrocellulose. Freund’s Complete Adjuvant is used for the initial injection and Freund’s Incomplete Adjuvant is used for subsequent injections. Other adjuvants are available.

Antibody Minimum and serum