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Non-Surgical Model of Sepsis and Inflammation

Service Description

In this model, a cecal slurry is used to induce septic peritonitis resulting in systemic bacteremia, organ infection and eventual systemic release of cytokines.  The model is highly reproducible, easy to monitor by a variety of endpoints, and closely mimics clinical sepsis.  By titrating the amount of cecal slurry used, the severity of the septic response can be adjusted to the needs of the experimenter.

Applications

Sepsis Graph

 Groups of 8 mice each received intraperitoneal (IP) injections at doses ranging from 0.5 gm/kg to 4 gm/kg.
Animals were monitored every hour and deaths recorded.  Survival was dose dependent.