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Cotton Rat Influenza Model

Service Description

The cotton rat (Sigmodon hispidus) is a commonly used model of influenza virus infection in humans because:

 

 

Influenza in Nasal Tissue

Viral titers in nasal tissue homogenates reached more than 105 PFU/g of tissue at Day 1 post infection and then declined to about 103 PFU/g of tissue
by Day 4 post infection. See figure at right.

 

 

 

 

  

 

Influenza in Lung Tissue

 

 

Viral titers in lung homogenates reached more than 106 PFU/g of tissue at Day 1 post infection and then declined to about 102 PFU/g of tissue by Day 4 post infection. See figure at right.