The smart solution for preclinical development

Depend on Noble Life Sciences as your partner for high-quality drug discovery & development services.

Contact Us Today »

Continuous Drug Infusion with an Implantable Osmotic Pump 

Description

Implantable osmotic pumps enable continuous, controlled dosing and thereby allow the achievement of steady state conditions and accurate compound delivery. Many types of compounds, e.g., small molecules, peptides or proteins, can be loaded into osmotic pumps. The pumps can then be implanted to provide continuous infusion with a controlled rate of release. Continuous infusion studies have been conducted with conventional mice, nude mice, NOD/SCID mice and rats.

Applications

 

ALZET® 2ML1 osmotic pumps were filled with the test compound in either of two different formulations and the concentration was adjusted to deliver 10mg/kg/day. Blood was sampled at 2, 3, 4, 6, 12, 24, and 28 hours and then daily for seven days.