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Continuous Drug Infusion with an Implantable Osmotic Pump 


Implantable osmotic pumps enable continuous, controlled dosing and thereby allow the achievement of steady state conditions and accurate compound delivery. Many types of compounds, e.g., small molecules, peptides or proteins, can be loaded into osmotic pumps. The pumps can then be implanted to provide continuous infusion with a controlled rate of release. Continuous infusion studies have been conducted with conventional mice, nude mice, NOD/SCID mice and rats.



ALZET® 2ML1 osmotic pumps were filled with the test compound in either of two different formulations and the concentration was adjusted to deliver 10mg/kg/day. Blood was sampled at 2, 3, 4, 6, 12, 24, and 28 hours and then daily for seven days.